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Sugar-Infused Iodine Antiseptic for Advanced Care
Introduction
In healthcare, reliable antiseptics are crucial for safe and effective wound management. This patented antiseptic solution uniquely combines iodine with sugar and/or sugar alcohol, creating a highly effective antiseptic with improved gentleness and stability. Ideal for both healthcare and consumer markets, this formula provides a modern solution to traditional antiseptics, promoting faster healing while ensuring safety and ease of application. This technology is an excellent fit for companies looking to expand their product line with an innovative, gentle, and highly effective antiseptic.
How It Works
The technology integrates iodine, known for its powerful antimicrobial properties, with a sugar or sugar alcohol component. This unique blend not only enhances the antiseptic’s efficacy but also reduces the potential for irritation, making it suitable for all skin types. The sugar or sugar alcohol helps stabilize the iodine, allowing for more controlled and prolonged antimicrobial action, which leads to effective disinfection with reduced side effects.
Key Benefits
- Effective Antimicrobial Action: The iodine component targets and kills bacteria, fungi, and other pathogens, making it highly effective for wound cleansing and infection prevention.
- Gentle on Skin: Combining iodine with sugar or sugar alcohol reduces the likelihood of skin irritation. This makes the formula safer for sensitive areas and various skin types, including children and those with sensitive skin.
- Enhanced Stability and Longevity: The sugar-alcohol combination helps stabilize the iodine, which ensures consistent antimicrobial action over time and extends the product’s shelf life.
- Versatile Applications: This antiseptic is versatile, with applications ranging from wound care in hospitals and clinics to consumer-friendly antiseptics in personal first-aid kits.
Why License This Technology
Licensing this patent provides an exciting opportunity for healthcare and personal care companies to bring a differentiated, advanced antiseptic to market. Unlike traditional formulas, this antiseptic is engineered to be both effective and gentle, addressing the needs of a wide demographic. By integrating this innovation, companies can offer a product that appeals to healthcare providers, patients, and everyday consumers alike. This sugar-infused iodine antiseptic represents the next generation of wound care, offering effective healing with reduced irritation—an asset for any health-focused brand.
The present invention relates to compositions that contain iodine intended primarily for tissue antisepsis, particularly skin antisepsis.
What is claimed is:
1. A tissue antiseptic composition comprising:
an antimicrobial agent selected from the group consisting of iodine (I2), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in a sufficient concentration to provide an available iodine concentration of 0.1 wt-% to 2 wt-%;
a sugar alcohol of a monosaccharide;
a vehicle that is a liquid at 23° C. wherein the vehicle is water;
a surfactant selected from the group consisting of an anionic surfactant, a zwitterionic surfactant, and a combination thereof; and
a thickener;
wherein the composition is a liquid at 23° C., has a pH of 2 to 6, and has a viscosity of no greater than 100,000 cps at 23° C.
2. The tissue antiseptic composition of claim 1 further comprising an alpha-hydroxyacid.
3. The tissue antiseptic composition of claim 2 wherein the alpha-hydroxyacid is present in an amount greater than 1 wt-%.
4. The tissue antiseptic composition of claim 3 wherein the alpha-hydroxyacid is present in an amount greater than 2.5 wt-%.
5. The tissue antiseptic of claim 1 wherein the zwitterionic surfactant comprises a sultaine, betaine, phospholipid, or a combination thereof.
6. The tissue antiseptic of claim 1 wherein the anionic surfactant comprises a phosphate, phosphonate, sulfate, sulfonate, or a combination thereof.
7. The tissue antiseptic composition of claim 1 wherein the composition further comprises a nonionic surfactant.
8. The tissue antiseptic composition of claim 1 wherein the vehicle further comprises a glycol.
9. The tissue antiseptic composition of claim 8 wherein the vehicle further comprises a polyethylene glycol having a molecular weight of less than 1500.
10. The tissue antiseptic composition of claim 1 which is free of an antimicrobial lipid.
11. The tissue antiseptic composition of claim 1 having a viscosity of less than 1000 cps.
12. The tissue antiseptic composition of claim 1 having a viscosity of greater than 10 cps.
13. The tissue antiseptic composition of claim 1 which reduces normal skin flora by at least 1 log in 2 minutes on dry human skin site using ASTM testing method E1173-93 and a 30-second scrub with gauze soaked in the composition using moderate pressure.
14. The tissue antiseptic composition of claim 1 which is stable at 50° C. for greater than 7 days with no visible changes.
15. The tissue antiseptic composition of claim 1 wherein the composition has a pH of 3 to 5.
16. The tissue antiseptic composition of claim 1 wherein the sugar alcohol is present in an amount of at least 1 wt-%, based on the total weight of the composition.
17. The tissue antiseptic composition of claim 16 wherein the sugar alcohol is present in an amount of at least 4 wt-%, based on the total weight of the composition.
18. The tissue antiseptic composition of claim 1 wherein the sugar alcohol is completely soluble with no solid dispersed therein.
19. The tissue antiseptic composition of claim 1 wherein the sugar alcohol is selected from xylitol, mannitol, and combinations thereof.
20. The tissue antiseptic composition of claim 1 having a viscosity of no greater than 50,000 cps at 23° C.
21. The composition of claim 1, wherein the sugar alcohol of a monosaccharide is present at a concentration of at least 0.25%.
22. A method of decolonizing the nasal passages of a subject, the method comprising applying the composition of claim 1 to the nasal passages of the subject.
23. A method of disinfecting the tissue of a subject, the method comprising applying the composition of claim 1 to the tissue of the subject.
24. A tissue antiseptic composition comprising:
an antimicrobial agent selected from the group consisting of iodine (I2), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in a sufficient concentration to provide an available iodine concentration of 0.1 wt-% to 2 wt-%;
a sugar alcohol of a monosaccharide;
a surfactant selected from the group consisting of an anionic surfactant, a zwitterionic surfactant, and a combination thereof;
a vehicle comprising water and a major amount of a water-soluble glycol humectant; and
a thickener;
wherein the composition is a liquid at 23° C., and has a pH of 2 to 6.
25. The tissue antiseptic composition of claim 24 wherein the composition further comprises a nonionic surfactant.
26. The tissue antiseptic composition of claim 24 wherein the glycol humectant is a polyethylene glycol having a molecular weight of less than 1500.
27. The tissue antiseptic composition of claim 24 further comprising an alpha-hydroxyacid.
28. The tissue antiseptic composition of claim 24 which is free of an antimicrobial lipid.
29. The tissue antiseptic composition of claim 24 wherein the composition has a pH of 3 to 5.
30. The tissue antiseptic composition of claim 24 wherein the sugar alcohol is present in an amount of at least 1 wt-%, based on the total weight of the composition.
31. The tissue antiseptic composition of claim 30 wherein the sugar alcohol is present in an amount of at least 4 wt-%, based on the total weight of the composition.
32. A method of decolonizing the nasal passages of a subject, the method comprising applying the composition of claim 24 to the nasal passages of the subject.
33. A method of disinfecting the tissue of a subject, the method comprising applying the composition of claim 24 to the tissue of the subject.
34. A tissue antiseptic composition comprising:
an antimicrobial agent selected from the group consisting of iodine (I2), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in a sufficient concentration to provide an available iodine concentration of 0.1 wt-% to 2 wt-%;
a sugar alcohol of a monosaccharide;
a vehicle wherein the vehicle is water;
a surfactant selected from the group consisting of an anionic surfactant, a zwitterionic surfactant, and a combination thereof; and
a hydroxycarboxylic acid;
wherein the composition has a viscosity of greater than 1000 cps and no greater than 100,000 cps at 23° C.; and
wherein the composition is a liquid at 23° C., and has a pH of 2 to 6.
35. The tissue antiseptic composition of claim 34 wherein the composition has a pH of 3 to 5.
36. The tissue antiseptic composition of claim 34 wherein the sugar alcohol is present in an amount of at least 1 wt-%, based on the total weight of the composition.
37. The tissue antiseptic composition of claim 36 wherein the sugar alcohol is present in an amount of at least 4 wt-%, based on the total weight of the composition.
38. A tissue antiseptic composition comprising:
an antimicrobial agent selected from the group consisting of iodine (I2), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in a sufficient concentration to provide an available iodine concentration of 0.1 wt-% to 2 wt-%;
xylitol;
a vehicle wherein the vehicle is water;
a surfactant selected from the group consisting of an anionic surfactant, a zwitterionic surfactant, and a combination thereof; and
a thickener;
wherein the composition is a liquid at 23° C., has a pH of 2 to 6, and has a viscosity of no greater than 100,000 cps at 23° C.
39. A tissue antiseptic composition comprising:
an antimicrobial agent selected from the group consisting of iodine (I2), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in a sufficient concentration to provide an available iodine concentration of 0.1 wt-% to 2 wt-%;
xylitol;
a vehicle wherein the vehicle is water;
a surfactant selected from the group consisting of an anionic surfactant, a zwitterionic surfactant, and a combination thereof; and
a hydroxycarboxylic acid;
wherein the composition has a viscosity of greater than 1000 cps and no greater than 100,000 cps at 23° C.; and
wherein the composition is a liquid at 23° C., and has a pH of 2 to 6.
40. A tissue antiseptic composition comprising:
an antimicrobial agent selected from the group consisting of iodine (I2), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in a sufficient concentration to provide an available iodine concentration of 0.1 wt-% to 2 wt-%;
a sugar alcohol of a monosaccharide;
a vehicle wherein the vehicle is water;
a surfactant selected from the group consisting of an anionic surfactant, a zwitterionic surfactant, and a combination thereof; wherein the anionic surfactant is selected from the group consisting of a phosphate, a phosphonate, a sulfate, a sulfonate, and a combination thereof; and
a thickener.
41. The tissue antiseptic of claim 40 wherein the surfactant is a zwitterionic surfactant.
42. The tissue antiseptic of claim 41 wherein the zwitterionic surfactant comprises a sultaine, betaine, phospholipid, or a combination thereof.
43. The tissue antiseptic of claim 40 wherein the surfactant is an anionic surfactant.
44. A method of decolonizing the nasal passages of a subject, the method comprising applying the composition of claim 40 to the nasal passages of the subject.
45. A method of disinfecting the tissue of a subject, the method comprising applying the composition of claim 40 to the tissue of the subject.
46. A tissue antiseptic composition comprising:
an antimicrobial agent selected from the group consisting of iodine (I2), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in a sufficient concentration to provide an available iodine concentration of 0.1 wt-% to 2 wt-%;
a sugar alcohol of a monosaccharide;
a vehicle wherein the vehicle is water;
a surfactant selected from the group consisting of a sultaine, a betaine, a phospholipid, a phosphate, a phosphonate, sulfate, a sulfonate, and a combination thereof; and
a thickener.
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Title
Liquid antiseptic compositions containing iodine and a sugar and/or sugar alcohol
Inventor(s)
Matthew T. Scholz
Assignee(s)
Solventum Intellectual Properties Co
Patent #
10052384
Patent Date
August 21, 2018