Advanced Skin Delivery with Nano Formulations

Introduction

This advanced nanoparticle formulation technology is a breakthrough in skin delivery, designed to improve how active ingredients penetrate and absorb into the skin. Perfectly suited for industries focused on skincare, pharmaceuticals, and cosmetics, this technology provides a method for transporting compounds into the skin with high precision, enhancing product efficacy and user satisfaction. It’s a sophisticated solution for brands aiming to offer the most effective products, giving them a competitive edge in a demanding market.

The Challenge: Limitations of Conventional Skin Delivery

Traditional skin delivery methods often face challenges in delivering active ingredients deep enough into the skin for optimal effect. Many skincare and therapeutic products are limited by low absorption rates, which reduce their effectiveness and fail to provide the benefits consumers expect. This lack of effective penetration is particularly problematic in products that contain high-value active ingredients, as these may remain largely unabsorbed on the skin’s surface, leading to wasted resources and diminished product efficacy. As the skincare and pharmaceutical industries continue to evolve, companies need reliable delivery systems that ensure these active compounds reach their intended target within the skin.

Advanced Skin Delivery with Nanoparticle Precision

This nanoparticle-based formulation allows active ingredients to be delivered precisely where they’re most effective. By encapsulating compounds in nanoparticles, the technology enables deeper skin penetration and controlled release, ensuring that the active ingredients reach their target without degradation. This innovation not only enhances the performance of topical products but also makes the process safer by protecting active compounds from environmental exposure. The technology is adaptable, working with various active ingredients, making it a versatile solution for both skincare and therapeutic applications.

Significant Advantages Across Key Sectors

For skincare and cosmetic companies, this technology enhances product performance by boosting the effectiveness of active ingredients, providing consumers with visible, lasting results. Pharmaceutical companies can use this delivery system to improve the bioavailability of therapeutic compounds, especially in treatments requiring precise topical application. Biotechnology firms benefit from the research potential this technology provides, as it offers a pathway to explore new skin-based drug delivery systems. Dermatology practices and health clinics also gain a valuable tool for developing or recommending products that meet higher standards of effectiveness and reliability in treating skin conditions.

A Strategic Move Toward Superior Skin Care

Licensing this advanced skin delivery technology offers companies a competitive advantage in the skincare, pharmaceutical, and cosmetics industries. With the ability to control ingredient absorption at a deeper level, brands can increase consumer trust by providing products that deliver real, measurable results. This technology supports a future where skincare and therapeutic products are more effective and more reliable, giving users an enhanced experience and companies a reputation for cutting-edge quality. It’s an opportunity for forward-thinking businesses to lead in product innovation, using a delivery system that meets the modern demand for scientifically backed, high-performance skin treatments.

Methods and formulations for treating a condition of the skin by delivering therapeutic formulations to the skin that translocates active substances across the stratum corneum barrier to a targeted skin tissue. The methods and formulations comprise active substances encapsulated within surface modified nanostructured lipid carrier nanoparticles.

The invention claimed is:

1. A formulation for topical application to a selected target skin tissue in the skin of a subject,

wherein said formulation comprises nanostructured lipid carrier nanoparticles encapsulating an active substance,
wherein the surface of the nanoparticles is modified with a cell penetrating peptide, and
wherein the nanoparticles comprise a blend of solid lipids and liquid lipids,
wherein the blend is solid at body temperature, and
wherein the formulation releases the active substance in a controlled manner upon application to the skin so that it penetrates the skin and is delivered to the epidermis to a depth of from about 80 to about 120 microns.
2. The formulation of claim 1, wherein the solid lipids are comprised of oil-based or lipidic medium carriers and the liquid lipids are comprised of an organic phase.
3. The formulation of claim 1, wherein the active substance is an anti-inflammatory agent.
4. The formulation of claim 1, wherein the active substance is suitable for the treatment of a disease or condition which is localized, or at least partially localized to the skin.
5. The formulation of claim 1, wherein the disease or condition is selected from the group consisting of psoriasis, irritant contact dermatitis, atopic dermatitis, contact dermatitis, inflammation, eczema, infections including bacterial and fungal infections, acne, rheumatoid arthritis and skin cancer.
6. The formulation of claim 1, wherein the solid lipids are selected from the group consisting of mono-, di- and triglycerides or mixtures thereof and nickel chelating lipids, and the liquid lipids are surfactants.
7. The formulation of claim 1, wherein the cell penetrating peptide is selected from the group consisting of a transactivating transcriptional activator protein (TAT), YARA, penetratin, and polyarginine (Rn) where Rn is Arg8, Arg11 or Arg 15.
8. The formulation of claim 7, wherein the TAT is Gly-Tyr-Arg-Lys -Lys-Arg-Arg-Gln-Arg-Arg-Arg-His-His-His-His-His-His.
9. The formulation of claim 1, wherein the cell penetrating peptides are attached to the nanoparticles with DOGS-NTA-Ni chelating lipid.
10. The formulation of claim 1, wherein the cell penetrating peptide is a polyarginine (Rn) where n is 8, 11, or 15.

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Title

Nanoparticle formulations for skin delivery

Inventor(s)

Mandip Singh Sachdeva, Ram Patlolla

Assignee(s)

Florida Agricultural and Mechanical University FAMU

Patent #

8715736

Patent Date

May 6, 2014

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