Breakthrough Dual-Action Receptor Therapy

Introduction

In the field of neuropharmacology, the development of selective ligands targeting both 5-HT1A and 5-HT7 receptors is nothing short of transformative. These dual-action receptor ligands are carefully engineered to offer a new approach in managing challenging neurological and psychological conditions, such as depression, anxiety, and other mood disorders. By focusing on both receptors simultaneously, this technology represents a critical step forward in delivering more precise, targeted therapies with fewer side effects than conventional treatments.

5-HT1A and 5-HT7 receptors play significant roles in the regulation of mood, cognition, and neural plasticity. While existing treatments often aim at one receptor or require multiple medications to achieve a broad effect, this dual-action therapy simplifies the approach. Acting on these two receptors concurrently enables a synergistic effect that can elevate therapeutic outcomes, potentially enhancing mood regulation, reducing cognitive impairments, and providing relief from both acute and chronic symptoms.

For companies looking to lead in the psychopharmacology market, this technology offers a unique proposition. By licensing this dual-ligand synthesis method, your organization can introduce a groundbreaking treatment option that sets a new standard in neurological and psychiatric care. Moreover, these dual ligands can be explored in novel delivery systems, creating opportunities for sustained-release options or even personalized medicine approaches tailored to individual patient needs.

The path to more effective, tolerable treatments for neurological conditions is clearer than ever with this innovation. Licensing this technology not only aligns your brand with the cutting edge of neuroscience but also establishes a foundation for long-term success in delivering impactful therapies for millions in need.

Novel dual 5-HT1A and 5-HT7 receptor ligands and methods of using the novel ligands to treat a neurological disorder are presented.

What is claimed is:

1. A compound comprising Formula (I), (II), (III), or (IV):
Figure US12006301-20240611-C00048
wherein X is C═O or CHand Ris AcHN or NH2;
Figure US12006301-20240611-C00049
wherein Ris Cl or H;
wherein Ris Cl, F, I, Br or H;
wherein Ris CHor H;
wherein Ris ═O, H or OH; and
wherein n is an integer from 1 to 3.
2. The compound of claim 1, wherein the compound comprises Formula (IV).
3. The compound of claim 2, wherein the Ris H.
4. The compound of claim 3, wherein the Ris Cl.
5. The compound of claim 4, wherein the Ris CH3.
6. The compound of claim 5, wherein the Ris ═O.
7. The compound of claim 6, wherein the n is 2.

8. A composition for treating a neurological disorder comprising:

a compound comprising Formula (I), (II), (III), or (IV):
Figure US12006301-20240611-C00050
wherein X is C═O or CHand Ris AcHN or NH2;
Figure US12006301-20240611-C00051
wherein Ris Cl or H;
wherein Ris Cl, F, I, Br or H;
wherein Ris CHor H;
wherein Ris ═O, H or OH;
wherein n is an integer from 1 to 3; and
a pharmaceutically acceptable carrier.
9. The composition of claim 8, wherein the compound comprises Formula (IV).
10. The composition of claim 9, wherein the Ris H.
11. The composition of claim 10, wherein the Ris Cl.
12. The composition of claim 11, wherein the Ris CH3.
13. The composition of claim 12, wherein the Ris ═O.
14. The composition of claim 13, wherein the n is 2.

15. A method of treating a neurological disorder in a patient in need thereof comprising:

administering a therapeutically effective amount of a composition to a patient in need thereof, the composition comprising

a compound comprising Formula (I), (II), (III), or (IV):
Figure US12006301-20240611-C00052
wherein X is C═O or CHand Ris AcHN or NH2;
Figure US12006301-20240611-C00053
wherein Ris Cl or H;
wherein Ris Cl, F, I, Br or H;
wherein Ris CHor H;
wherein Ris ═O, H or OH;
wherein n is an integer from 1 to 3; and
a pharmaceutically acceptable carrier.
16. The method of claim 15, wherein the neurological disorder is selected from the group consisting of depression, anxiety, schizophrenia, and cognitive deficits caused by Alzheimer disease.
17. The method of claim 15, wherein the compound comprises Formula (IV) wherein the Ris H and the Ris Cl.
18. The method of claim 17, wherein the Ris CH3.
19. The method of claim 18, wherein the Ris ═O.
20. The method of claim 19, wherein the n is 2.

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Title

And synthesis of dual 5-HT1A and 5-HT7 receptor ligands

Inventor(s)

Seth Y. Ablordeppey

Assignee(s)

Florida Agricultural and Mechanical University FAMU

Patent #

12006301

Patent Date

June 11, 2024

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