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Composite Coating for Titanium Implants
Introduction
A composite coating and method for preparing the composite coating on titanium implants for tissue culture and tissue engineering is provided. The implants are characterized in that the titanium component to be coated is placed in a aqueous solution containing calcium cations, phosphate anions, and dispersed carbon nanoparticles (such as single layer graphene oxide or graphene oxide) in an amount of about 0.05%-1.50% by weight relative to the total weight of aqueous solution. The dimensions of the dispersed graphene oxide should be around, but not limited to, 300-800 nm (X-Y), while their thickness is about 0.7-1.2 nm. The aqueous solution with carbon nanoparticles is prepared by mixing for at least 72 h in temperature in range 20-35° C. and sonicated before electrodeposition process. In the prepared solution is further placed titanium which acts as cathode element (may be the implant), and anode which can be, for example, a platinum rod. Between the cathode and anode is set a potential from −1.3V to −1.7V which results in coating formation by electrodeposition. The titanium implant before the electrodeposition process is treated in sodium hydroxide of HF to improve coating formation and thickness.
1. A method for preparing a composite coating on an implant comprising:
providing an aqueous electrolytic solution, wherein the aqueous electrolytic solution comprises calcium cations, phosphate anions, and dispersed carbon nanoparticles;
placing the implant into the aqueous electrolytic solution; and
applying a voltage between a cathode and anode for electrodeposition of the calcium cations, phosphate anions, and dispersed carbon nanoparticles onto the implant.
2. The method of claim 1, further comprising etching the implant prior to the step of placing the implant into the aqueous electrolytic solution.
3. The method of claim 2, wherein the etching is performed by treating the implant with sodium hydroxide.
4. The method of claim 2, wherein the etching is performed by treating the implant with hydrofluoric acid.
5. The method of claim 1, wherein the implant is comprised of titanium.
6. The method of claim 1, wherein the implant is comprised of an alloy of titanium.
7. The method of claim 1, wherein the aqueous electrolytic solution is prepared by mixing the calcium cations, phosphate anions, and dispersed carbon nanoparticles for at least 72 hours at temperature in a range of about 20° C. to about 35° C. and the aqueous electrolytic solution is sonicated prior to electrodeposition.
8. The method of claim 1, further comprising reversibly connecting the cathode element in electrical connection with the implant and placing the anode in electrical connection with the aqueous electrolytic solution.
9. The method of claim 1, wherein the voltage applied between the cathode and anode is set to a potential from −1.3V to −1.7V for electrodeposition.
10. The method of claim 1, wherein the dispersed carbon nanoparticles are graphene oxide, single layer graphene oxide, or a combination thereof.
11. The method of claim 1, wherein an amount of the dispersed carbon nanoparticles included in the aqueous electrolytic solution is between 0.05% and 1.5% by total weight of the aqueous electrolytic solution and is calculated by:
mGO[g]=m r[g]·% GO
where:
mGO [g]=mass of the dispersed carbon nanoparticles included set in grams,
mr[g]=mass of the aqueous electrolytic solution of the calcium cations and phosphate anions set in grams, and
% GO=the dispersed carbon nanoparticles addition to the aqueous electrolytic solution set in percentage.
12. A method for preparing a composite coating on a titanium implant for tissue engineering comprising:
providing an aqueous electrolytic solution, wherein the aqueous electrolytic solution consists essentially of calcium cations, phosphate anions, and dispersed carbon nanoparticles, and wherein the dispersed carbon nanoparticles are selected from the group consisting of graphene oxide, single layer graphene oxide, or a combination thereof;
placing the titanium implant into the aqueous electrolytic solution;
physically attaching a cathode element to the titanium implant and providing an anode element in electrical connection with the aqueous electrolytic solution, wherein the anode comprises platinum; and
applying a voltage between the cathode and the anode for electrodeposition of the calcium cations, phosphate anions, and dispersed carbon nanoparticles onto the titanium implant.
13. The method of claim 12, wherein the calcium cations are provided by dissolved hydrated or unhydrated calcium nitrate.
14. The method of claim 12, wherein the phosphate anions are phosphate anions (V) and are provided by dissolved hydrated or unhydrated potassium phosphate.
15. The method of claim 12, further comprising etching the titanium implant prior to the step of placing the titanium implant into the aqueous electrolytic solution.
16. The method of claim 15, wherein the etching is performed by treating the titanium implant with sodium hydroxide.
17. The method of claim 15, wherein the etching is performed by treating the titanium implant with hydrofluoric acid.
18. The method of claim 12, wherein the titanium implant is comprised of an alloy of titanium.
19. The method of claim 12, wherein the dispersed carbon nanoparticles have dimensions in a range of about 300-800 nm and a thickness of around 0.7-1.2 nm.
20. The method of claim 12, wherein an amount of the dispersed carbon nanoparticles included in the aqueous electrolytic solution is between about 0.05% and 1.5% by total weight of the aqueous electrolytic solution and is calculated by:
mGO[g]=m r[g]·% GO
mGO [g]=mass of the dispersed carbon nanoparticles included set in grams,
mr[g]=mass of the aqueous electrolytic solution of the calcium cations and phosphate anions set in grams, and
% GO=the dispersed carbon nanoparticles addition to the aqueous electrolytic solution set in percentage.
21. An implant with a composite coating comprising hydroxyapatite and carbon nanoparticles wherein the implant is coated with the composite coating by placing the implant into the aqueous electrolytic solution comprising calcium cations, phosphate anions, and dispersed carbon nanoparticles and wherein the implant is subjected to electrodeposition of the calcium cations, phosphate anions, and dispersed carbon nanoparticles.
22. The implant with a composite coating of claim 21, wherein an amount of the dispersed carbon nanoparticles included in the aqueous electrolytic solution is between about 0.05% and 1.5% by total weight of the aqueous electrolytic solution and is calculated by:
mGO[g]=m r[g]·% GO
where:
mGO [g]=mass of the dispersed carbon nanoparticles included set in grams,
mr[g]=mass of the aqueous electrolytic solution of the calcium cations and phosphate anions set in grams, and
% GO=the dispersed carbon nanoparticles addition to the aqueous electrolytic solution set in percentage.
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Title
Method for obtaining a composite coating on titanium implants for tissue engineering
Inventor(s)
Bartlomiej Wysocki, Danuta Leszczynska, Wojciech Swieszkowski, Krzysztof Jan Kurzydlowski
Assignee(s)
Jackson State University
Patent #
20170088969
Patent Date
March 30, 2017