Enhanced Skin Delivery with Nano Precision

Introduction

This innovative technology uses surface-modified, multilayered nanostructures to optimize dermal delivery, offering unmatched precision in transporting active ingredients deep into the skin. Designed for applications in skincare, pharmaceuticals, and cosmetics, this technology enhances the effectiveness of treatments, ensuring that active compounds reach their intended depth for maximum efficacy. For brands committed to delivering superior performance in skin health, this technology provides a sophisticated method to stand out in the competitive landscape.

The Challenge: Deep and Consistent Absorption

Standard dermal delivery methods often struggle with achieving consistent absorption, limiting the effectiveness of even high-quality active ingredients. Many compounds remain on the skin’s surface, where they are unable to penetrate to the target areas where they are most beneficial. This limitation is especially problematic for products designed to treat specific skin concerns, as poor absorption reduces the visible effects and can undermine consumer trust. As demand for high-performing skincare and therapeutic products grows, companies need delivery systems that consistently deliver active ingredients at effective depths.

Advanced Delivery with Surface-Modified Nanostructures

This multilayered nanostructure technology addresses these challenges by leveraging surface modification to optimize how active ingredients interact with the skin. By creating targeted pathways, the technology enables enhanced absorption and controls the release rate of active compounds, ensuring sustained effectiveness. Each nanostructure’s modified surface is tailored to improve adhesion and penetration, making it highly adaptable to various active ingredients and allowing precise delivery. This approach protects the integrity of sensitive ingredients and provides a level of delivery that’s challenging to achieve with conventional systems.

Key Benefits for Skincare and Health Industries

For skincare and cosmetic brands, this technology means improved product performance, as consumers experience noticeable results more quickly and consistently. Pharmaceutical companies can use this delivery system for targeted topical treatments, increasing the bioavailability of active ingredients and enhancing therapeutic outcomes. Biotechnology firms benefit from the potential for extensive research applications, as the technology provides a robust platform to explore new dermal treatment solutions. Dermatologists and health professionals can leverage this advanced delivery system for more effective treatments, offering patients options that address skin concerns with higher reliability and precision.

Investing in the Future of Skincare Technology

Licensing this enhanced skin delivery technology positions your organization as a leader in advanced skincare and therapeutic solutions. By offering a product that maximizes ingredient performance through precise, controlled absorption, you meet the growing demand for reliable and effective skin treatments. This technology is a strategic tool for brands seeking to elevate their product offerings and solidify their reputation as providers of high-quality, scientifically backed treatments. It’s an opportunity to differentiate your business with a forward-thinking approach that combines cutting-edge nanotechnology with a deep understanding of skincare and therapeutic needs.

Dermal delivery is best suited for the various skin diseases or disorders. However, the stratum corneum limits the permeation of number of suitable pharmaceutical agents for dermal delivery. Certain embodiments of the present invention include surface modified multilayered nanostructures. The modification was completed by using fatty acids enabling delivery of a significant amount of one or more pharmaceutical agent(s) into deeper layers of the epidermis and dermis to treat skin diseases or disorders. Each active pharmaceutical agent can be encapsulated into the separate layers of the nanostructures.

What is claimed is:

1. A composition for dermal delivery of at least one pharmaceutical agent through a stratum corneum of a subject, comprising each of the at least one a pharmaceutical agent admixed with at least one layer of polymeric nanostructures, wherein the at a least one layer of polymeric nanostructures includes an outer layer with an outer surface covalently bonded by at least one spacer linked to at least one skin-permeating fatty acid such that the at least one spacer linked to the at least one skin-permeating fatty acid extends from the outer surface of the outer layer of polymeric nanostructures to facilitate penetration of the composition through the stratum corneum of the subject, wherein the at least one spacer linked to the at least one fatty acid is a fatty acid-PEG-succinimidyl glutamate ester structure.
2. The composition of claim 1, wherein the fatty acid is oleic acid.
3. The composition of claim 1, wherein the at least one pharmaceutical agent is selected from the group consisting of spantide II, cyclosporine A, alpha-MSH, capsaicin and ketoprofen.
4. The composition of claim 1, further comprising at least one polymer.
5. The composition of claim 4, wherein the at least one polymer is PLGA.
6. The composition of claim 1, further comprising at least one lipid or polymer.
7. The composition of claim 6, wherein the at least one lipid is a derivative of glycerol.
8. The composition of claim 1, further comprising an emulsifying agent.
9. The composition of claim 8, wherein the emulsifying agent is polyvinyl alcohol.
10. The composition of claim 1, further comprising a surfactant.
11. The composition of claim 10, wherein the surfactant is polyoxyethylene (20) sorbitan monooleate.
12. The composition of claim 1, further comprising an anti-foaming agent.
13. The composition of claim 12, wherein the anti-foaming agent is sorbitan monooleate.
14. The composition of claim 1, further comprising a cross-linking agent.
15. The composition of claim 14, wherein the cross-linking agent is selected from the group consisting of sodium tripolyphosphate and glutaraldehyde.
16. A carrier for dermal delivery of at least one pharmaceutical agent through a stratum corneum of a subject, comprising each of the at least one a pharmaceutical agent and at least one layer of polymeric nanostructures, wherein the at least one layer of polymeric nanostructures includes an outer layer with an outer surface covalently bonded by at least one spacer linked to at least one skin-permeating fatty acid such that the at least one spacer linked to the at least one skin-permeating fatty acid extends from the outer surface a of the outer layer of polymeric nanostructures to facilitate penetration of the composition through the stratum corneum, admixed with a carrier agent, whereby the carrier is formulated wherein the at least one spacer linked to the at least one fatty acid is a fatty acid-PEG-succinimidyl glutamate ester structure.
17. The carrier of claim 16, wherein the formulated carrier is selected from the group consisting of aqueous dispersions, nanogels, lotions, powders, emulsion, liniments, ointments, creams and patches.
18. A composition for dermal delivery of at least one pharmaceutical agent, comprising:

the at least one pharmaceutical agent;
a layer of nanostructures having a formula of formula I
Figure US08865206-20141021-C00001
at least one polymer, wherein the at least one polymer is PLGA;
at least one lipid, wherein the at least one lipid is 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE);
an emulsifying agent, wherein the emulsifying agent is polyvinyl alcohol;
a surfactant, wherein the surfactant is polyoxyethylene (20) sorbitan monooleate;
an anti-foaming agent, wherein the anti-foaming agent is sorbitan monooleate; and
a cross-linking agent, wherein the cross-linking agent is sodium tripolyphosphate.

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Title

Surface modified multilayered nanostructures for dermal delivery

Inventor(s)

Mandip Sachdeva, Punit Shah

Assignee(s)

Florida Agricultural and Mechanical University FAMU

Patent #

8865206

Patent Date

October 21, 2014

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