Next-Gen Glucose Detection with Nanofiber Precision

Introduction

This cutting-edge carbon nanofiber sensor technology provides a non-enzymatic approach to glucose detection, offering a more accurate, reliable, and efficient method for monitoring blood sugar levels. Ideal for medical device companies, biotechnology firms, and diabetes management providers, this sensor technology enables more precise glucose readings without the need for enzymes, making it a robust solution for both consumer and clinical applications. It represents a breakthrough in glucose monitoring, addressing key industry challenges and offering enhanced performance for better patient outcomes.

The Challenge: Improving Glucose Detection Accuracy

Traditional glucose monitoring systems often rely on enzyme-based sensors, which can degrade over time, leading to inconsistent results and reduced accuracy. For individuals managing diabetes, the ability to trust glucose readings is crucial for proper disease management and quality of life. Additionally, enzyme-based sensors may be susceptible to interference from external factors, limiting their effectiveness. As the healthcare industry pushes toward more accurate, reliable, and long-lasting glucose detection methods, there is a growing need for non-enzymatic solutions that provide consistent performance without the drawbacks associated with enzymatic degradation.

Carbon Nanofiber Sensors: A Game-Changing Solution

This carbon nanofiber sensor technology addresses these issues by using a non-enzymatic approach that leverages the high surface area and conductivity of carbon nanofibers to detect glucose levels with exceptional precision. The non-enzymatic method eliminates the risk of sensor degradation, offering longer-lasting accuracy and reducing the need for frequent recalibration. Additionally, the nanofiber structure enables faster, more reliable glucose detection, improving both patient experience and clinical outcomes. This technology is suitable for integration into wearable devices, continuous glucose monitors, and handheld meters, providing flexibility across a range of healthcare applications.

Key Benefits for Healthcare and Diagnostics

For medical device manufacturers, this technology enables the development of more reliable glucose monitoring systems that can enhance patient care and improve device longevity. Healthcare providers benefit from increased accuracy and fewer false readings, ensuring better patient management and treatment plans. Biotechnology firms can leverage this technology for further research into non-enzymatic detection methods, opening new avenues for diagnostic innovation. Diabetes management providers will find this technology valuable for improving patient compliance and health outcomes, offering a solution that reduces the burdens of frequent testing.

Investing in the Future of Glucose Monitoring

Licensing this nanofiber glucose detection technology positions your organization as a leader in the next generation of glucose monitoring. By offering a non-enzymatic solution that enhances precision and durability, your company can provide a more reliable tool for diabetes management, meeting the growing demand for accurate, easy-to-use monitoring systems. This technology supports better patient care, reduces costs associated with sensor maintenance, and advances healthcare innovation in glucose monitoring.

A general methodology for the development of sensitive and selective sensors that can achieve a low cost detection of glucose without using enzymes is disclosed. The method uses carbon nanofiber (CNF) array electrodes for the electrochemical detection of glucose. CNFs grown by plasma enhanced chemical vapor deposition (PECVD) with diameters ranging from 13-160 nm and a height of approximately one micrometer are preferred. The CNFs have a sensitivity of 2.7 μA/mM cm2 and detection limit of 2 mM. Also provided are methods of preparing the CNF sensors and kit components. Methods of using such CNF sensors for detecting target agents, particularly glucose, are also provided.

The invention claimed is:

1. A non-enzymatic glucose sensor, comprising an electrode having carbon nanofibers on a transition-metal coated silicon substrate, wherein the carbon nanofibers after growth are not further modified.
2. The sensor of claim 1 wherein the carbon nanofibers have diameters between 13 to 160 nm.
3. The sensor of claim 2 wherein the diameter of the carbon nanofibers is between 60 to 70 nm.
4. The sensor of claim 2, wherein the carbon nanofibers have a density of 40 fibers/μm2.
5. The sensor of claim 1, wherein the electrode surface area is at least 100 mm2.
6. The sensor of claim 1 wherein the electrode capacitance is 0.2 μc/mV.

7. A method for detecting glucose in a sample, comprising:

contacting one or more sensors of claim 1 with a sample under conditions sufficient to allow the sample to contact the sensors; and detecting glucose, wherein detection of glucose indicates the presence of glucose in the sample.
8. The method of claim 7 wherein the electrode is comprised of carbon nanofibers having diameters between 13 to 160 nm.
9. The method of claim 7 wherein an amount of glucose in the sample is between 10 to 2,000 mg/dL.
10. The method of claim 7 wherein the sample is selected from the group consisting of saliva, blood or urine.
11. A kit comprising: one or more non-enzymatic glucose sensors of claim 1 and at least one table for correlating detected glucose level.
12. A method for detecting hydrogen peroxide in a sample, comprising: contacting one or more sensors of claim 1 with a sample under conditions sufficient to allow the sample to bind to the sensor; detecting hydrogen peroxide, wherein detection of hydrogen peroxide indicates the presence of hydrogen peroxide in the sample.
13. A non-enzymatic hydrogen peroxide sensor, comprising an electrode having carbon nanofibers on a transition-metal and metal oxide coated silicon substrate, wherein the carbon nanofibers after growth are not further modified.

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Title

Carbon nanofiber sensor for non-enzymatic glucose detection and methods of glucose detection using such carbon nanofiber sensor

Inventor(s)

Tamara Floyd SMITH, Julaunica TIGNER, Jessica KOEHNE

Assignee(s)

Tuskegee University

Patent #

11035820

Patent Date

June 15, 2021

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